However, because the paper was published in Japanese, it failed to appear in the standard indexing and abstracting journals and this finding remained unknown until ROSEN et al. However, for several years we have had the opportunity to study a clinico-pathological picture, observed mainly in children, characterized by the formation of granulomas with heavy eosinophilic infiltration in the abdominal cavity. We propose the name Angiostr01zgylfls costaricensis, n. Surgical specimens obtained from several hospitals of the country were used in this study. From fixed material the worms were obtained by dissecting the small arteries of the intestinal wall and in unfixed specimens they were liberated by digestion with pepsin.
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However, because the paper was published in Japanese, it failed to appear in the standard indexing and abstracting journals and this finding remained unknown until ROSEN et al.
However, for several years we have had the opportunity to study a clinico-pathological picture, observed mainly in children, characterized by the formation of granulomas with heavy eosinophilic infiltration in the abdominal cavity.
We propose the name Angiostr01zgylfls costaricensis, n. Surgical specimens obtained from several hospitals of the country were used in this study. From fixed material the worms were obtained by dissecting the small arteries of the intestinal wall and in unfixed specimens they were liberated by digestion with pepsin.
Drawings were made with the aid of a camera lucida. Measurements are given in millimeters unless otherwise specified. Angiostrongylus costaricensis n.
Body filiform in both sexes, tapering toward both ends. The caudal end of the male curves ventrally, with a well developed copulatory bursa; in the female thc caudal end is roughly conical and slightly curved. Cuticle transversely striated and thicker toward both ends. Excretory pore immediately posterior to the base of the club-shaped esophagus. MALE: 3 specimens : Body length Spicules slender, equal, striated, ending in two hook-shaped formations, 0. Gubernaculum present, 0.
In the copulatory bursa ventral rays fused except for the distal fifth, with bud-shaped endings; the ventrolateral is slightly longer than the ventroventral. The lateral rays arise from a common trunk and are of similar size, the posterolateral and mediolateral are fused in the proximal half and the externolateral separates from these after its emergence from the common trunk. The externodorsal ray arises near the base of the laterals and is separate from the dorsal; it is long, slender, and larger at thc distal end.
The dorsal ray is thick, short, terminating in three tips; the central one is short, knob-like, and the laterals beak-shaped. Vulva situated 0. HOST: Man is not considered to be the normal host; animal hosts are as yet unknown. Normal habitat: unknown. In man the worms are localized in small branches of the mesenteric artery. More recently two other species have been described: A. A comparative study of these fourteen species with the parasite found in Costa Rica revealed many characteristic differences whose point by point description would be too long to include here.
Therefore, we have limited ourselves only to the description of the most important differences, which in out opinion justify the establishment of a new species. In the first place, on the basis of the parasite size, we are able to ignore all those whose length is less than one half that of A.
The length of the spicules, an important taxonomic character, permits us to disregard all those species in which these structures measure more than 0. These species are A. The spicules of A. There were also. We think that A. An important characteristic is the presence of a conspicuous spine at the tip of the tail of the female of A. A similar structure occurs only in A.
Another important characteristic is the presence of a gubernaculum in A. The first species described with this structure was A. Although he interpreted this area as a telamon, it is more than likely a gubernaculum. The presence of a gubernaculum in A. Working with Ash unpubIished data , it was found that careful examination of A.
Fever was usually high and sometimes lasting up to two months. Anorexia was often observed and one third of the patients experienced vomiting. The physical examination showed an intra-abdominal mass which could cause confusion with malignant tumors or acute appendicitis of other etiology. Rectal examination was usually painful and sometimes the tumoral mass could be palpated.
The most important laboratory findings were leucocytosis ranging from 10, to 52, per mm 3 with eosinophilia from 11 to 81 per cent.
In a few cases, eosinophilia was lower than 10 per cent. X-ray examination showed alteration of the intestinal wall as demonstrated by a filling defect Fig. Anatomo-pathoIogical studies revealed that lesions were, in most cases, localized in the appendix, but some were found to extend to the terminal portion of the ileum, cecum, fue first part of the ascending colon, and to the regional lymph nodes The main characteristic was thickening and hardening of the edematous intestinal wall, with milliary yellowish granulomatous infiltration.
These lesions could produce incomplete or complete obstruction. In some cases, necrotic processes could produce perforation. Less frequently, lesions were observed in the transverse and descending colon and sigmoid. Histologically the lesions appeared as a granulomatous inflammation with massive eosinophilic infiltration, involving all the layers of the intestinal wall.
This' same inflammatory process was observed to aHect the regional lymph nodes. Thin-shelled, oval, embryonated eggs were scattered in the lesion Fig. Occasionally, the embryos reached the larval stage, but the larvae remained enclosed within the egg shell Fig. In cases of longer evolution, the eggs appeared inside the giant cells. Sections of the adult parasite could be found in both mesenteric arteries and their intramural branches Fig. These worms sometimes produced arteritis and thrombosis Fig.
We believe this difference is caused by different life cycles, known only for A. In any case, A. However, the larvae apparently do not hatch, which suggests the impossibility of these larvae ever entering the intestinal lumen and returning to the soil to complete their life cycle. In the human cases in which we have had the opportunity to screen the feces for larvae, the results were negative. The authors are indebted to Dr.
Lawrence R. Alfonso Trejos, Dr. Alan Altman and Dr. Thomas Lau for their help in preparation of the English manuscript. It can be distinguished from other species of the genus on the basis of its size, the length of the spicules, the position of the vulva and the morphology and position of the bursal rays.
The parasite localizes in the small mesenteric arteries, especially in the ileocecal region, where it produces arteritis and thrombosis. Eggs in various stages of embryonation were found scattered in the tissues of the intestinal wall and regional lymph nodes, eliciting a granulomatous inflammatory reaction with in.
A cause of parasitic meningitis in the Pacific-rat lungworms. Hawaii; Farm. Angiostrongylus cantonensis Nematoda: Metastrongylidae as a causative agent of eosinophilie meningitis of man in Hawaii and Tahiti. Angiostrongylus sandarse sp. Nematoda: Metastrongyloidea a lungworm of rodents in Mozambique, East Africa. The gubernaculum of Angiostrongylus cantonesis Chen. Present status of Angiostrongylus cantonensis infection in man and animals in the tropics.
ASH, L. Angiostrongylus michiganensis sp. Nematoda: Metastrongyloidea. VIII: On a collection of nematodes from Nigerian mammals chiefly rodents. Parasitology, ROSEN Memorandum on the first report of Angiostrongylus in man by Nomura and Lin, Angiostrongylus chabaudi n. Lincet, Alegre, 4: CHEN, H. Un nouveau nematode pulmonaire, Pulmonema cantonensis, n. The genus Aelurostrongylus Cameron, Nematoda: Metasuongylidae , and its relation with description of Parafilaroides, gen.
Parasitic meningoencephalitis in Hawaii, a new parasitic disease of man. Hawaii Med. The systematic position of the genera Haemostrongylus Wost. Charkov Vet. The life history of the rat lungworm Angiostrongylus cantonensis Chen Nematoda: Metasuongylidae. A new lungworm Angiostrongylus sciuri n. B-Sciences Naturelles Costarric,
Biology - Angiostrongyliasis, Abdominal
The related species A. The main definitive host for A. Slugs in the families Veronicellidae and Limacidae are the typical intermediate hosts. Aberrant abdominal infections have been documented in humans, non-human primates, and other mammals, including raccoons and one opossum. Abdominal angiostrongyliasis has mainly been reported from parts of Latin America and the Caribbean. Although A.
[Human Angiostrongyliasis Caused by Angiostrongylus Costaricensis]
Language: English French. Human abdominal angiostrongyliasis HAA is a parasitic disease caused by the accidental ingestion of the nematode Angiostrongylus costaricensis in its larval form. Human infection can lead to severe ischemic and inflammatory intestinal lesions, sometimes complicated by life-threatening ileal perforations. Only one case had been reported in Martinique, an Island in the French Antilles, in