DIGAMI TRIAL PDF

The current trial studied insulin-glucose infusion versus standard care in acute myocardial infarction AMI patients with elevated blood glucose levels. At 24 hours, the insulin-glucose treated patients had lower glucose levels 9. At a mean follow-up of 3. At a mean follow-up of 7. The median survival was 7. Insulin-glucose infusion followed by a multidose insulin therapy improved long-term survival in diabetic patients after AMI.

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The current trial studied insulin-glucose infusion versus standard care in acute myocardial infarction AMI patients with elevated blood glucose levels. At 24 hours, the insulin-glucose treated patients had lower glucose levels 9. At a mean follow-up of 3. At a mean follow-up of 7. The median survival was 7. Insulin-glucose infusion followed by a multidose insulin therapy improved long-term survival in diabetic patients after AMI. Possible mechanisms for this benefit are that intense insulin may restore impaired platelet function, decrease PAI-1 activity, and possibly improve metabolism of noninfarcted areas.

The period of enrollment was to ; therefore, the findings might be less robust in the current era with potent antiplatelet therapy, lipid-lowing therapy, antihypertensive therapy, and improved glycemic control. Lancet Diabetes Endocrinol ;May [Epub ahead of print].

Randomised trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction DIGAMI study : effects on one year mortality.

J Am Coll Cardiol ; Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ ; Clinical Topics: Dyslipidemia, Lipid Metabolism. Description: The current trial studied insulin-glucose infusion versus standard care in acute myocardial infarction AMI patients with elevated blood glucose levels.

Principal Findings: At 24 hours, the insulin-glucose treated patients had lower glucose levels 9. Interpretation: Insulin-glucose infusion followed by a multidose insulin therapy improved long-term survival in diabetic patients after AMI.

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Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction - DIGAMI 1

Objectives: We tested how insulin-glucose infusion followed by multidose insulin treatment in diabetic patients with acute myocardial infarction affected mortality during the subsequent 12 months of follow-up. Background: Despite significant improvements in acute coronary care, diabetic patients with acute myocardial infarction still have a high mortality rate. Results: The two groups were well matched for baseline characteristics. Blood glucose decreased from After 1 year 57 subjects

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The DIGAMI trial: Insulin-glucose infusion in diabetics with acute MI [Classics Series]

These pages are best viewed with Netscape version 3. When viewed with other browsers, some characters or attributes may not be rendered correctly. People with diabetes who suffer an acute myocardial infarction MI are at markedly increased risk of future cardiovascular morbidity and mortality. The DIGAMI study compared "conventional" anti-diabetic therapy to intensive insulin therapy consisting of acute insulin infusion during the early hours of MI and thrice-daily subcutaneous insulin injection for the remainder of the hospital stay and a minimum of 3 months thereafter. Although there was an overall reduction in adverse outcomes in patients receiving the intensive insulin regimen, it is unclear which component the IV insulin infusion or the intensive chronic therapy was responsible.

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DIGAMI Trial

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