FUNDAMENTOS HEMATOLOGIA RUIZ ARGUELLES PDF

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The sticky platelet syndrome SPS is a common cause of both arterial and venous thrombosis, being a dominant autosomal disease with qualitative platelet alterations and familial occurrence. It is characterized by platelet hyperreactivity with increased platelet aggregability in response to low concentrations of platelet agonists: epinephrine, adenosine diphosphate, or both.

The clinical manifestations involve venous or arterial thrombosis, recurrent pregnancy loss, and fetal growth retardation. To analyze the localization of the thrombotic episodes in a cohort of Mexican mestizo patients with SPS.

Between and , 86 Mexican mestizo patients with SPS as the single thrombophilic condition were prospectively identified; all of them had a history of thrombosis. There were 15 males and 71 females. Arterial thrombosis was mainly pulmonary thromboembolism, whereas venous thromboses were identified most frequently in the lower limbs. Mexican mestizo population with SPS is mainly female; the type I of the condition is the most frequent; both arterial and venous thrombosis can occur, and they are mainly pulmonary embolism and lower limbs venous thrombosis, respectively.

The sticky platelet syndrome SPS is a common cause of arterial and venous thrombosis. Initially described by Holiday in at the Ninth Conference on Stroke and Cerebral Circulation in Arizona, it is the second most common hereditary thrombophilic condition in Mexican mestizos.

We analyzed Mexican mestizo patients with a clinical marker of primary thrombophilia and a history of thrombosis. All patients had a proven angiography or doppler ultrasound thrombotic episode and one of the clinical markers of a primary thrombophilic condition 1 , 5 , 7 — 11 : a family history of thrombosis, b thrombosis at uncommon anatomic locations, and c resistance to conventional antithrombotic therapy.

The SPS was defined by specific laboratory methods described by Mammen et al, 4 , 12 , 13 Kubisz et al, 6 , 7 , 14 and Ruiz-Delgado et al.

All of them were referred to our facility for evaluation after having suffered a thrombotic event and displaying at least one clinical marker of thrombophilia. Sticky platelet syndrome is an autosomal inherited platelet disorder, with familial occurrence.

Type II SPS is more frequent in Caucasians, 2 , 3 , 25 whereas type I is the most frequent in Mexican mestizos, 1 , 25 a population in which this condition is the second most frequent cause of thrombophilia. The thrombotic episodes stemming from SPS have been described as anticoagulant resistant, 6 , 25 , 24 this being important in selecting the antithrombotic therapeutic approach of such patients.

In a prospective study, we have shown that the rethrombosis rate in persons with SPS treated with adequate antiplatelet drugs is as low as 3. In previous papers, we have shown that some persons with the SPS do thrombose sometimes in the presence of other thrombophilic conditions, either inherited or acquired, 15 thus supporting the concept of multifactorial thrombophilia.

In summary, we have described some features of the thrombotic episodes of the SPS presenting in Mexican mestizos, which are somehow different from those described in Caucasians: type I is the most frequent; it presents mainly in females; it is more frequently found in venous than in arterial thrombosis; and it is a frequent cause of lower limbs thromboses and pulmonary embolism.

Additional studies are needed to define more precisely other clinical features of the SPS. Read article at publisher's site DOI : To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Clin Appl Thromb Hemost , 19 6 , 29 Jun Cited by 4 articles PMID: Rev Invest Clin , 54 5 , 01 Sep Cited by 2 articles PMID: Hematology , 18 4 , 19 Feb Cited by 5 articles PMID: Semin Thromb Hemost , 40 5 , 09 Jun Cited by 7 articles PMID: Expert Rev Hematol , 9 1 , 09 Dec Coronavirus: Find the latest articles and preprints. Europe PMC requires Javascript to function effectively. Recent Activity. Recent history Saved searches.

Search articles by 'Brizeida Azamar-Solis'. Azamar-Solis B 1 ,. Cantero-Fortiz Y 2 ,. Search articles by 'Juan Carlos Olivares-Gazca'. Olivares-Gazca JC 1 ,. Olivares-Gazca JM 1 ,. Search articles by 'Guillermo J Ruiz-Delgado'. Ruiz-Delgado GJ 1 ,.

Affiliations 6 authors 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Free full text. Clin Appl Thromb Hemost. Published online Apr PMID: Guillermo J. Author information Article notes Copyright and License information Disclaimer. Email: moc. Received Jan 15; Accepted Mar 5. Go to:. Keywords: sticky platelet syndrome, platelet hyperaggregability, Mexican mestizo.

Table 1. Open in a separate window. Table 2. Table 3. Abbreviation: NS, non significant. Figure 1. Turk J Hematol. Sticky platelet syndrome and cerebral infarction in young adults. Progress in the understanding of sticky platelet syndrome. Semin Thromb Hemost. Mammen EF. Am J Hematol. Sticky platelet syndrome: an important cause of life-threatening complications. Expert Rev Hematol. Sticky platelet syndrome: history and future perspectives. Rev Colomb Obstet Ginecol. Emre T, Demir M. Sticky platelet syndrome in patients with uninduced venous thrombosis.

Turk J Haematol. Nine kindreds of familial sticky platelet syndrome phenotype. Rev Hematol Mex. Sticky platelet syndrome. Primary thrombophilia in Mexico. A comprehensive prospective study indicates that most cases are multifactorial. Sticky platelets syndrome: a frequent cause of primary thrombophilia.

J Invest Dermatol. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet. Primary thrombophilia in Mexico III: a prospective study of the sticky platelet syndrome.

Are the platelets activated in sticky platelet syndrome? Thromb Res. Bilateral simultaneous anterior ischaemic optic neuropathy associated with sticky platelet syndrome. Br J Ophthalmol. Sticky platelet syndrome and anterior ischaemic optic neuropathy. Clin Experiment Ophthalmol. Transient visual loss triggered by scuba diving in a patient with a petrous epidermoid and combined thrombotic risk factors.

Pathophysiol Haemost Thromb. Bick RL. Sticky platelet syndrome: a common cause of unexplained arterial and venous thrombosis. Genetic origin of the sticky platelet syndrome.

The sticky platelet syndrome.

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